This strain carries the Tnfsf4Ath1-PERA/EiJ resistance allele of the wild-derived strain PERA, which confers a high serum HDL cholesterol level and resistance to the development of atherosclerosis when the mice are fed a high fat diet on the C57BL/6J strain background. The C57BL/6J allele results in low HDL cholesterol levels and susceptibility to diet induced atherosclerosis.
Genetic Background | Generation |
---|---|
000664 C57BL/6J |
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | Tnfsf4 | tumor necrosis factor (ligand) superfamily, member 4 |
This strain carries the Tnfsf4Ath1-PERA/EiJ resistance allele of the wild-derived strain PERA, which confers a high serum HDL cholesterol level and resistance to the development of atherosclerosis when the mice are fed a high fat diet on the C57BL/6J strain background. The C57BL/6J allele results in low HDL cholesterol levels and susceptibility to diet induced atherosclerosis.
Mice of the strain PERA, descended from wild mice trapped in Peru, are resistant to atherosclerosis and have elevated HDL levels. A congenic strain was constructed by crossing a PERA mouse to a C57BL/6J mouse, then selecting mice having high HDL levels for each subsequent backcross to C57BL/6J. At N5, the high HDL/ atherosclerosis resistance trait was mapped and found to localize to the same genomic position as Ath1. The congenic has now been backcrossed for ten generations. (The PERA subline used to construct this strain is now extinct.) (Paigen, 2000)
B6.PERA-Tnfsf4Ath1-PERA/EiJ was transfered to the production colony at JAX from Dr. Beverly Paigen's colony, also at JAX. The PERA/Ei inbred used as the donor strain in this congenic originally came from Peru. The original was trapped by Olga Atteck for M.E. Wallace, University of Cambridge, in 1961 in a Peruvian Yard used to dry maize cobs in Nana Village, Rimac Valley, Peru. The mice were held in a small, closed colony by Wallace. In 1971, at approximately F25, mice from his colony were sent to E.M. Eicher and T.H. Roderick at JAX. PERA/Ei and PERA/Rk were established immediatelly as separate colonies.
Allele Name | PERA/EiJ |
---|---|
Allele Type | QTL |
Allele Synonym(s) | Ath1r |
Gene Symbol and Name | Tnfsf4, tumor necrosis factor (ligand) superfamily, member 4 |
Gene Synonym(s) | |
Strain of Origin | PERA/EiJ |
Chromosome | 1 |
Molecular Note | This allele confers elevated high-density lipoprotein (HDL) cholesterol levels and resistance to diet-induced atherosclerosis relative to the C57BL/6J allele. |
When using the B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn mouse strain in a publication, please cite the originating article(s) and include JAX stock #002671 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Tnfsf4<Ath1-PERA/EiJ> |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.