| Allele Name | transgene insertion 7, Walter Koch |
| Allele Type | Transgenic (Constitutively active, Inserted expressed sequence) |
| Allele Synonym(s) | (CAM)alpha1B-AR; CAM7; CAMalpha1B-AR |
| Gene Symbol and Name | Tg(CAMalpha1b)7Wjk, transgene insertion 7, Walter Koch |
| Gene Synonym(s) | |
| Promoter | Myh6, myosin, heavy polypeptide 6, cardiac muscle, alpha, mouse, laboratory |
|---|
| Expressed Gene | ADRA1B, alpha1B-adrenergic receptor , hamster |
|---|
| Strain of Origin | Not Specified |
| Chromosome | UN |
| Molecular Note | Sequence encoding hamster adrenergic receptor alpha 1b (ADRA1B), containing 3 missense mutations (R288K, K290H, A293L) to make it constitutively active, was adjoined to the mouse myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6) promoter. Cardiac-specific expression of the mutant ADRA1B was indicated by radio ligand binding assay to be approximately 3-fold higher than that of the endogenous Adra1b. In addition to line 7 (CAM7), lines 21 (CAM21) and 56 (CAM56) were also generated. They also overexpress by approximately 3-fold. |
| Mutations Made By | Dr. Walter Koch, Duke University Medical Center |
