These mice carry a spontaneous re-mutation of the mouse dreher (Lmx1adr) gene that causes skeletal defects, hyperactivity, abnormal gait, deafness, white belly spotting, and hypoplasia of Mullerian duct derivatives.
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Lmx1a | LIM homeobox transcription factor 1 alpha |
These mice carry a spontaneous re-mutation of the mouse dreher (Lmx1adr) gene that causes skeletal defects, hyperactivity, abnormal gait, deafness, white belly spotting, and hypoplasia of Mullerian duct derivatives.
The dreher 6 Jackson mutation arose spontaneously at The Jackson Laboratory in 1992 in the strain C3H/HeJ-Pou1f1dw-J/J (stock#000510). After 9 generations of intercrossing on this background, a C3H/HeSnJ male was bred with an ovarian transplant host from a dr-6J/dr-6J donor and their offspring were intercrossed. No dwarf mice had been seen in many years of breeding indicating the dwarf Jackson mutation had been bred out. At generation +F9N1F7 a heterozygote, identified through C3H derived sequence at D1Mit425, D1Mit202, and D1Mit 15, was outcrossed to C57BL/6JEi and the new strain was maintained by backcrossing MIT marker-typed heterozygotes to C57BL/6JEi. Between 2000 and 2002, embryos were cryopreserved from C57BL/6J females bred with heterozygous males at or beyond generation N5.
Allele Name | dreher 6 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Lmx1a, LIM homeobox transcription factor 1 alpha |
Gene Synonym(s) | |
Strain of Origin | C3H/HeJ-Pou1f1dw-J/J |
Chromosome | 1 |
Molecular Note | The deletion of exons 4-8 prevented protein production. |
When using the dreher 6 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #002624 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Lmx1a<dr-6J> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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