WLC/MorJ

Stock number: 002600
Research areas: Cancer Research

Detailed description

WLC/MorJ represents a endogenous and exogenous MMTV-free genetic background. WLC/MorJ does not develop mammary tumors and no exogenous MMTV is detectable by PCR. WLC/MorJ serves as the strain background for WLC.C2-H2^d.GR-Mtv2/Mor (Stock #003153).

Development

WLC/MorJ was derived from inbreeding MMTV-free wild mice from Lake Casitas, CA. The mice (called ev^-) were originally isolated by Murray Gardner at USC in the late 70's. In the mid-80's, Robert Cardiff at UC Davis partially inbred the strain. DW Morris obtained F11-F13 mice from Cardiff in 1988. Morris bred WLC/MorJ to the F30 generation. The Jackson Laboratory received the colony in 1995.