Ap3b1pe-7J was proven to be an allele of Ap3b1 by an allele test mating with Ap3b1pe. Generally, mutations in Ap3b1 affect skin, hair, and eye color. Skin of the ears, feet, and tail of homozygous Ap3b1pe-7J mice are lighter than wild-type mice. The eye color and coat color are influenced by dilution of non-agouti brown pigmentation from the strain background DBA/1LacJ. Eyes of homozygous adult Ap3b1pe-7J mice have a ruby cast and their coat color is a diluted gray-brown.
The pearl 7 Jackson mutation arose spontaneously in the DBA/1LacJ inbred strain when it was at generation F131. This mutant subline was maintained coisogenic on this background by intercrossing heterozygotes and homozygotes. In 2002 embryos were cryopreserved from homozygous males at generation F131+16 with either homozygous or heterozygous females at generation F131+14N1F1.
|Allele Name||pearl 7 Jackson|
|Gene Symbol and Name||Ap3b1, adaptor-related protein complex 3, beta 1 subunit|
|Strain of Origin||DBA/1LacJ|
|General Note||Mice from this strain were not tested for differences in lysosomal enzymes or for platelet storage pool deficiency, both of which are common in other Ap3b1 mutations.|
|Molecular Note||The molecular lesion in pe7J has not yet been resolved.|