Mice homozygous for the Il4tm1Nnt targeted mutation are viable and fertile, but generate smaller liver granulomas that contained fewer eosinophils and no mast cells. Expression of the IL-4-dependent molecules IgE and IgG1 as well as B cell surface class II and CD23 is impaired. Production of Th2-derived cytokines is significantly reduced. T and B cell development is normal, and the lack of IL-4 appears not to affect CTL-mediated immunity.
|Allele Name||targeted mutation 1, Nancy Noben-Trauth|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||IL-4-; il4-|
|Gene Symbol and Name||Il4, interleukin 4|
|Strain of Origin||C57BL/6J|
|Molecular Note||A neomycin resistance cassette was inserted into exon 3 of the gene.|
|Mutations Made By|| |
When using the IL-4- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002518 in your Materials and Methods section.