Mice homozygous for this Ntrk3tm1 targeted mutation (commonly referred to as trkC) die by 2-3 weeks of age. Homozygous mutant mice lack proprioceptive and cochlear neurons and have a reduction in vestibular neurons.
Dr. Mariano Barbacid, Centro Nacional de Investigaciones Oncol
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Ntrk3 | neurotrophic tyrosine kinase, receptor, type 3 |
Mice homozygous for this Ntrk3tm1 targeted mutation (commonly referred to as trkC) die by 2-3 weeks of age. Homozygous mutant mice lack proprioceptive and cochlear neurons and have a reduction in vestibular neurons.
Part of exon K2 of the Ntrk3 gene was replaced using a vector containing the neo resistance gene. This strain was generated on a 129 genetic background. It has subsequently been bred to C57BL/6 mice.
Allele Name | targeted mutation 1, Mariano Barbacid |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | trkC-; trkCTK; trkCK- |
Gene Symbol and Name | Ntrk3, neurotrophic tyrosine kinase, receptor, type 3 |
Gene Synonym(s) | |
Strain of Origin | 129S2/SvPas |
Chromosome | 7 |
Molecular Note | Insertion of a neomycin cassette into exon K2, which encodes part of the kinase domain of the protein. An alternatively spliced mRNA was detectable in an RNase protection analysis on tissues derived from homozygous mutant mice; these transcripts spliced from exon K1 to K3. A partial protein product is predicted to be expressed from this allele. |
Mutations Made By | Dr. Mariano Barbacid, Centro Nacional de Investigaciones Oncol |
When maintaining a live colony, this mutant can be maintained by mating heterozygous siblings or by mating heterozygous mice with normal wildtype siblings. Homozygous mice die by 2-3 weeks of age.
When using the trkCTKcite the originating article(s) and include JAX stock #002481 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Ntrk3<tm1Bbd> |
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