B6;129S2-Ntrk3^tm1Bbd/J

Stock number: 002481
Product name: trkC^TKResearch areas: Cancer Research, Immunology, Inflammation and Autoimmunity Research, Neurobiology Research, Sensorineural Research

Detailed description

Mice homozygous for this Ntrk3^tm1 targeted mutation (commonly referred to as trkC) die by 2-3 weeks of age. Homozygous mutant mice lack proprioceptive and cochlear neurons and have a reduction in vestibular neurons.

Development

Part of exon K2 of the Ntrk3 gene was replaced using a vector containing the neo resistance gene. This strain was generated on a 129 genetic background. It has subsequently been bred to C57BL/6 mice.

Allele

Symbol: Ntrk3^tm1Bbd
Name: targeted mutation 1, Mariano Barbacid
MGI accession ID: MGI:1888375
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Ntrk3
Marker name: neurotrophic tyrosine kinase, receptor, type 3
Chromosome: 7
Strain of origin: 129S2/SvPas
Molecular note: Insertion of a neomycin cassette into exon K2, which encodes part of the kinase domain of the protein. An alternatively spliced mRNA was detectable in an RNase protection analysis on tissues derived from homozygous mutant mice; these transcripts spliced from exon K1 to K3. A partial protein product is predicted to be expressed from this allele.