Mice homozygous for the Ntrk1tm1 targeted mutation (commonly referred to as trkA) die by 2-3 weeks of age. Homozygous mutant mice show a complete lack of both nociceptive and superior cervical ganglion neurons.
Dr. Mariano Barbacid, Centro Nacional de Investigaciones Oncol
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Ntrk1 | neurotrophic tyrosine kinase, receptor, type 1 |
Mice homozygous for the Ntrk1tm1 targeted mutation (commonly referred to as trkA) die by 2-3 weeks of age. Homozygous mutant mice show a complete lack of both nociceptive and superior cervical ganglion neurons.
Part of exons 6 and 7 of the Ntrk1 gene were replaced using a vector containing the neo resistance gene. The 129-derived D3 ES cell line was used. It has subsequently been bred to C57BL/6 mice.
Allele Name | targeted mutation 1, Mariano Barbacid |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | trkTK; trkA-; trkAK- |
Gene Symbol and Name | Ntrk1, neurotrophic tyrosine kinase, receptor, type 1 |
Gene Synonym(s) | |
Strain of Origin | 129S2/SvPas |
Chromosome | 3 |
Molecular Note | Sequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts. |
Mutations Made By | Dr. Mariano Barbacid, Centro Nacional de Investigaciones Oncol |
When maintaining a live colony, this mutant can be maintained by mating heterozygous siblings or by mating heterozygous mice with normal wildtype siblings. Homozygous mice die by 2-3 weeks of age.
When using the trkTK mouse strain in a publication, please cite the originating article(s) and include JAX stock #002480 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Ntrk1<tm1Bbd> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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