B6;129S2-Ntrk1^tm1Bbd/J

Stock number: 002480
Product name: trk^TK

Detailed description

Mice homozygous for the Ntrk1^tm1 targeted mutation (commonly referred to as trkA) die by 2-3 weeks of age. Homozygous mutant mice show a complete lack of both nociceptive and superior cervical ganglion neurons.

Development

Part of exons 6 and 7 of the Ntrk1 gene were replaced using a vector containing the neo resistance gene. The 129-derived D3 ES cell line was used. It has subsequently been bred to C57BL/6 mice.

Allele

Symbol: Ntrk1^tm1Bbd
Name: targeted mutation 1, Mariano Barbacid
MGI accession ID: MGI:1888374
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Ntrk1
Marker name: neurotrophic tyrosine kinase, receptor, type 1
Chromosome: 3
Strain of origin: 129S2/SvPas
Molecular note: Sequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts.