Mice homozygous for the Syt1tm1Sud targeted mutation die 1-2 days after birth. Homozygous mutant mice show an impaired synchronous, fast Ca2+-dependent neurotransmitter release.
Dr. Thomas C. Sudhof, Stanford University School of Medicine
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Syt1 | synaptotagmin I |
Mice homozygous for the Syt1tm1Sud targeted mutation die 1-2 days after birth. Homozygous mutant mice show an impaired synchronous, fast Ca2+-dependent neurotransmitter release.
Allele Name | targeted mutation 1, Thomas C Sudhof |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | Syt- |
Gene Symbol and Name | Syt1, synaptotagmin I |
Gene Synonym(s) | |
Strain of Origin | 129S4/SvJae |
Chromosome | 10 |
Molecular Note | A 5' portion of the exon encoding amino acids 270 through 308 and the preceding intron were replaced with a neomycin selection cassette. In addition to the coding sequence, the intron acceptor site was deleted. Lysates derived from the brains of homozygous mice were shown to contain less than 5% of the amount of a truncated form of the encoded protein compared to controls by immunoblotting. |
Mutations Made By | Dr. Thomas Sudhof, Stanford University School of Medicine |
Mice homozygous for the Syt1tm1Sud targeted mutation die 1-2 days after birth. When maintaining a live colony, heterozygous mice may be bred together or to wildtype mice from the colony. The expected coat color from breeding is black.
When using the B6;129S-Syt1tm1Sud/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002478 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Syt1<tm1Sud> |
Frozen Mouse Embryo | B6;129S-Syt1<tm1Sud>/J | $2595.00 |
Frozen Mouse Embryo | B6;129S-Syt1<tm1Sud>/J | $2595.00 |
Frozen Mouse Embryo | B6;129S-Syt1<tm1Sud>/J | $3373.50 |
Frozen Mouse Embryo | B6;129S-Syt1<tm1Sud>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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