Il2ra knock-out mice may be useful for studying lymphoproliferative disorder, hemolytic anemia and inflammatory bowel disease.This strain also is available on the BALB background (Stock No. 036023) and C57BL/6 congenic background (Stock No. 002952).
Dr. Frederick W. Alt, Children's Hospital
Mice homozygous for the Il2ratm1Dw targeted mutation are are characterized by a lymphoproliferative disorder, hemolytic anemia and an inflammatory bowel disease beginning at approximately 9 weeks of age. Homozygous females may not be healthy enough to breed. Il2ra is also known as p55 gene chain, Ly43, CD25.
|Allele Name||targeted mutation 1, Dennis M Willerford|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||CD25-; CD25KO; IL-2Ralpha-; IL-2Ralpha KO; IL2Ralpha-|
|Gene Symbol and Name||Il2ra, interleukin 2 receptor, alpha chain|
|Strain of Origin||129S4/SvJae|
|Molecular Note||A neomycin resistance cassette replaced a 5.5 kb segment of the gene, containing exons 2 and 3, which encode for the binding site of the protein.|
|Mutations Made By|| |
Dr. Dennis Willerford, Children's Hospital
When maintaining a live colony, heterozygous mice may be bred as together. Such matings may produce less homozygotes than Mendelian expectations. Homozygous females may not be healthy enough to breed. The expected coat color from breeding is black.
When using the IL-2Rα- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002462 in your Materials and Methods section.