B6;129S4-Il2ra^tm1Dw/J

Stock number: 002462
Product name: IL-2Rα^-
Research areas: Cancer Research, Immunology, Inflammation and Autoimmunity Research, Mouse/Human Gene Homologs

Description

Il2ra knock-out mice may be useful for studying lymphoproliferative disorder, hemolytic anemia and inflammatory bowel disease.This strain also is available on the BALB background (Stock No. 036023) and C57BL/6 congenic background (Stock No. 002952).

Detailed description

Mice homozygous for the Il2ra^tm1Dw targeted mutation are are characterized by a lymphoproliferative disorder, hemolytic anemia and an inflammatory bowel disease beginning at approximately 9 weeks of age. Homozygous females may not be healthy enough to breed. Il2ra is also known as p55 gene chain, Ly43, CD25.

This strain also is available on the BALB background (Stock No. 036023) and C57BL/6 congenic background (Stock No. 002952).

Allele

Symbol: Il2ra^tm1Dw
Name: targeted mutation 1, Dennis M Willerford
MGI accession ID: MGI:1857192
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Il2ra
Marker name: interleukin 2 receptor, alpha chain
Chromosome: 2
Strain of origin: 129S4/SvJae
Molecular note: A neomycin resistance cassette replaced a 5.5 kb segment of the gene, containing exons 2 and 3, which encode for the binding site of the protein.