Il2ra knock-out mice may be useful for studying lymphoproliferative disorder, hemolytic anemia and inflammatory bowel disease.This strain also is available on the BALB background (Stock No. 036023) and C57BL/6 congenic background (Stock No. 002952).
Dr. Frederick W. Alt, Children's Hospital
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Il2ra | interleukin 2 receptor, alpha chain |
Mice homozygous for the Il2ratm1Dw targeted mutation are are characterized by a lymphoproliferative disorder, hemolytic anemia and an inflammatory bowel disease beginning at approximately 9 weeks of age. Homozygous females may not be healthy enough to breed. Il2ra is also known as p55 gene chain, Ly43, CD25.
This strain also is available on the BALB background (Stock No. 036023) and C57BL/6 congenic background (Stock No. 002952).
Allele Name | targeted mutation 1, Dennis M Willerford |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | CD25-; CD25KO; IL-2Ralpha-; IL-2Ralpha KO; IL2Ralpha- |
Gene Symbol and Name | Il2ra, interleukin 2 receptor, alpha chain |
Gene Synonym(s) | |
Strain of Origin | 129S4/SvJae |
Chromosome | 2 |
Molecular Note | A neomycin resistance cassette replaced a 5.5 kb segment of the gene, containing exons 2 and 3, which encode for the binding site of the protein. |
Mutations Made By | Dr. Dennis Willerford, Children's Hospital |
When maintaining a live colony, heterozygous mice may be bred as together. Such matings may produce less homozygotes than Mendelian expectations. Homozygous females may not be healthy enough to breed. The expected coat color from breeding is black.
When using the IL-2Rα- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002462 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Il2ra<tm1Dw> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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