Somitogenesis is disturbed in these Notch1 deficient mice.
Dr. Ronald A. Conlon, Case Western Reserve Univ, School of Med
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Notch1 | notch 1 |
In these Notch1 deficient mice, somitogenesis is disturbed and there is a probable defect in chorio-allantoic connection. Homozygotes die at embryonic day 9.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
The targeting vector used deleted a large portion of the Notch1 gene.
Allele Name | targeted mutation 1, Ronald L Conlon |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | N1delta1; Notch-; Notchdelta1; Notch1-; Notch1tm1Con/J |
Gene Symbol and Name | Notch1, notch 1 |
Gene Synonym(s) | |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | 2 |
Molecular Note | Deletion of sequences encoding the EGF repeats 28 to 36, three Notch repeats, the transmembrane domain and CDC10/SWI6 repeats, and replacement with a neomycin gene. |
Mutations Made By | Dr. Ronald Conlon, Case Western Reserve Univ, School of Med |
This strain is maintained by breeding heterozygous mice to normal wildtype siblings. Expected coat color from breeding:Albino
When using the STOCK Notch1tm1Con/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002445 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Notch1<tm1Con> |
Frozen Mouse Embryo | STOCK Notch1<tm1Con>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | STOCK Notch1<tm1Con>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | STOCK Notch1<tm1Con>/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | STOCK Notch1<tm1Con>/J Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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