The Grid2Lc-J mutation arose spontaneously in a BALB/cByJ stock and displays a semidominant pattern of inheritance. In the heterozygote, this mutation results in an early loss of Purkinje cells in the cerebellum, which is followed by the overt symptom of an ataxic gait first observed at postnatal day 13 (P13). A portion of animals homozygous for the mutation die within P0; the remaining homozygotes die by P25. The mutation maps to mouse Chromosome (Chr) 6 between markers D6Rck314 and D6Rck361, a chromosomal segment that contains the lurcher (Lc) locus.
The semi-dominant mutation lurcher Jackson (Grid2Lc-J) arose spontaneously in the inbred strain BALB/cByJ at The Jackson Laboratory in 1993. The stock was maintained by mating a heterozygote with a wild type (+/+) sibling. It was cryopreserved in 1995 by mating C57BL/6J females with heterozygous males at generation F?+5 to generate embryos.
|Allele Name||lurcher Jackson|
|Gene Symbol and Name||Grid2, glutamate receptor, ionotropic, delta 2|
|Strain of Origin||BALB/cByJ|
|Molecular Note||This allele comprises a nucleotide substitution that causes a change in an amino acid in the third transmembrane domain of Grid2.|