B6.129P2-Igh-J^tm1Cgn/J

Stock number: 002438
Product name: J_HT
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Detailed description

Mice homozygous for the Igh-J^tm1Cgn targeted mutation fail to produce functional B-cells as they lack the gene for the heavy chain joining region. Also known as J_HT.

Allele

Symbol: Igh-J^tm1Cgn
Name: targeted mutation 1, University of Cologne
MGI accession ID: MGI:1861941
Generation method: Targeted
Attributes: Null/Knockout; Modified regulatory region
Marker symbol: Igh-J
Marker name: immunoglobulin heavy chain, joining region
Chromosome: 12
Strain of origin: 129P2/OlaHsd
Molecular note: Deletional recombination mediated by cre-loxP resulted in the loss of the exons encoding the joining region and the intron enhancer of the immunoglobulin heavy chain locus (IgH).