These mice carry a spontaneous re-mutation at the Cdh23 locus characterized by circling, head-tossing, deafness, and hyperactivity typical of circling mutants.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Cdh23 | cadherin 23 (otocadherin) |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | H2-K | histocompatibility 2, K region |
Mice homozygous for the waltzer Jackson spontaneous mutation (Cdh23v-J) exhibit the circling, head-tossing, deafness, and hyperactivity typical of circling mutants. Homozygous mutant mice are very similar to other waltzer mutants (Cdh23v and Cdh23v-2J). Most homozygotes are deaf from birth. Abnormalities of the inner ear include degeneration of the organ of Corti, spiral ganglion, stria vascularis, and saccular macula. Double heterozygotes with shaker-1 (Cdh23v/+ Myo7ash1/+) become deaf by 3 to 6 months of age. Double heterozygotes show degeneration in the organ of Corti, stria vascularis, and spiral ganglion similar to that of Cdh23v-J homozygotes, but less severe and with much later onset. Viability and breeding ability are somewhat reduced.
Allele Name | waltzer Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | Bob; bobby; nm1971 |
Gene Symbol and Name | Cdh23, cadherin 23 (otocadherin) |
Gene Synonym(s) | |
Strain of Origin | B6.C-H2-Kbm1/ByJ |
Chromosome | 10 |
Molecular Note | A single G residue at coding nucleotide 3505 was deleted in this allele. This mutation causes a translational frame shift and premature termination of the encoded protein. |
Allele Name | b haplotype mutation 1 |
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Allele Type | Spontaneous |
Allele Synonym(s) | bm1; H(z1); H-2ba; H-2bm1; Kbm1 |
Gene Symbol and Name | H2-K, histocompatibility 2, K region |
Gene Synonym(s) | |
Strain of Origin | C57BL/6By |
Chromosome | 17 |
General Note | Genbank ID for this allele: X56624 |
Molecular Note | The bm1 mutation contains 7 nucleotide differences resulting in amino acid substitutions at codon 152 (glutamate to alanine), codon 155 (arginine to tyrosine) and codon 156 (leucine to tyrosine). |
When using the waltzer Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #002432 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Cdh23<v-J>, Homozygous for H2<bm1> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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