Overview

Also Known As:waltzer Jackson

These mice carry a spontaneous re-mutation at the Cdh23 locus characterized by circling, head-tossing, deafness, and hyperactivity typical of circling mutants.

Genetic overview

Genetic Background	Generation

Cdh23^v-J

Allele Type	Gene Symbol	Gene Name
Spontaneous	Cdh23	cadherin 23 (otocadherin)

Allele Type	Gene Symbol	Gene Name
Spontaneous	H2-K	histocompatibility 2, K region

Research Applications

Developmental Biology Research
Mouse/Human Gene Homologs
Neurobiology Research
Sensorineural Research
Immunology, Inflammation and Autoimmunity Research

View All Research Applications

Base Price

Starting at:

$2,854.50 Domestic price Cryo Recovery

View Price List

Details

Detailed Description

Mice homozygous for the waltzer Jackson spontaneous mutation (Cdh23^v-J) exhibit the circling, head-tossing, deafness, and hyperactivity typical of circling mutants. Homozygous mutant mice are very similar to other waltzer mutants (Cdh23^v and Cdh23^v-2J). Most homozygotes are deaf from birth. Abnormalities of the inner ear include degeneration of the organ of Corti, spiral ganglion, stria vascularis, and saccular macula. Double heterozygotes with shaker-1 (Cdh23^v/+ Myo7a^sh1/+) become deaf by 3 to 6 months of age. Double heterozygotes show degeneration in the organ of Corti, stria vascularis, and spiral ganglion similar to that of Cdh23^v-J homozygotes, but less severe and with much later onset. Viability and breeding ability are somewhat reduced.

Genetics

Cdh23^v-J

Allele Symbol: Cdh23^v-J

Allele Name	waltzer Jackson
Allele Type	Spontaneous
Allele Synonym(s)	Bob; bobby; nm1971
Gene Symbol and Name	Cdh23, cadherin 23 (otocadherin)
Gene Synonym(s)
Strain of Origin	B6.C-H2-K^bm1/ByJ
Chromosome	10
Molecular Note	A single G residue at coding nucleotide 3505 was deleted in this allele. This mutation causes a translational frame shift and premature termination of the encoded protein.

H2-K^bm1

Allele Symbol: H2-K^bm1

Allele Name	b haplotype mutation 1
Allele Type	Spontaneous
Allele Synonym(s)	bm1; H(z1); H-2^ba; H-2^bm1; K^bm1
Gene Symbol and Name	H2-K, histocompatibility 2, K region
Gene Synonym(s)
Strain of Origin	C57BL/6By
Chromosome	17
General Note	Genbank ID for this allele: X56624
Molecular Note	The bm1 mutation contains 7 nucleotide differences resulting in amino acid substitutions at codon 152 (glutamate to alanine), codon 155 (arginine to tyrosine) and codon 156 (leucine to tyrosine).

Disease/Phenotype

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Usher syndrome type 1D

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23^v-J related

Developmental Biology Research
- Defects in Cell Adhesion Molecules
Mouse/Human Gene Homologs
- deafness, autosomal recessive 12 (DFNB12)
- Usher syndrome, type ID
  - USH1D
Neurobiology Research
- Hearing Defects
  - deafness, nonsyndromic autosomal recessive 12 (DFNB12)
Sensorineural Research
- Hearing Defects
  - deafness, nonsyndromic autosomal recessive 12 (DFNB12)

Immunology, Inflammation and Autoimmunity Research
- CD Antigens, Antigen Receptors, and Histocompatibility Markers

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Cdh23^v-J/Cdh23^v-J
B6.C-H2-K/ByJ

behavior/neurological phenotype

ataxia

head tossing
- vertical head tossing

novel environmental response-related retropulsion
- mice shuffle backwards when placed on a smooth surface

hearing/vestibular/ear phenotype

abnormal otolith morphology
- deficiencies in both utricular and saccular otoliths

increased or absent threshold for auditory brainstem response
- mice are deaf

References

Additional References

Bolz H; von Brederlow B; Ramirez A; Bryda EC; Kutsche K; Nothwang HG; Seeliger M; Cabrera Md; Vila MC; Molina OP; Kubisch C; Gal A. 2001. Mutation of CDH23, encoding a new member of the cadherin gene family, causes usher syndrome type 1D Nat Genet 27(1):108-12PubMed: 11138009 MGI: J:66740

Additional - Cdh23^v-J related

Additional - H2-K^bm1 related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Citation
When using the waltzer Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #002432 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Pricing & Availability

Cryo Recovery

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service/Product	Description	Price
	Heterozygous or Wild-type for Cdh23<v-J>, Homozygous for H2<bm1>

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

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Animal Care and Use for SERVICES

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No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

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Also Known As:waltzer Jackson

Genetic overview

Research Applications

Base Price

Detailed Description

Cdh23v-J

Allele Symbol: Cdh23v-J

H2-Kbm1

Allele Symbol: H2-Kbm1

Disease Terms

Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Cdh23v-J related

Mammalian Phenotype Terms by Genotype

Genotype: Cdh23v-J/Cdh23v-JB6.C-H2-K/ByJ

behavior/neurological phenotype

hearing/vestibular/ear phenotype

References

Additional References

Additional - Cdh23v-J related

Additional - H2-Kbm1 related

Genotyping Protocols

Citation

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200

Live Mouse

Cryorecovery - Pricing

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms Of Use

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Cdh23^v-J

Allele Symbol: Cdh23^v-J

H2-K^bm1

Allele Symbol: H2-K^bm1

Genotype: Cdh23^v-J related

Genotype: Cdh23^v-J/Cdh23^v-J
B6.C-H2-K/ByJ

Additional - Cdh23^v-J related

Additional - H2-K^bm1 related