These MT-TGFα (MT42) mice express a transgene containing the human TGFA (transforming growth factor alpha) cDNA.
Dr. Glenn T. Merlino, National Institutes of Health
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence, Humanized sequence) |
In the STOCK Tg(MtTGFA)42Lmb/J line liver lesions develop in a progressive fashion, with neoplasia confirmed at autopsy (average age 13 months). Pancreas showed progressive hyperplasia of the stroma, tubular structures and ductular metaplasia, with penetrance of 100%. Unlike mice from the FVB/N-Tg(MtTGFA)100Lmb/J line, STOCK Tg(MtTGFA)42Lmb/J mice do not develop mammary tumors.
Expressed Gene | TGFA, transforming growth factor alpha, human |
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Site of Expression |
Allele Name | transgene insertion 42, Glenn Merlino |
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Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | line MT42; MT/TGF-alpha line MT42; MT42; MT-TGF-alpha; Tg(Mt1-TGFA)42Lmb; TGF-alpha |
Gene Symbol and Name | Tg(MtTGFA)42Lmb, transgene insertion 42, Glenn Merlino |
Gene Synonym(s) | |
Promoter | Mt1, metallothionein 1, mouse, laboratory |
Expressed Gene | TGFA, transforming growth factor alpha, human |
Strain of Origin | CD-1 |
Chromosome | UN |
Molecular Note | This transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Dr. Glenn Merlino, National Institutes of Health |
When maintaining a live colony, hemizygous mice may be bred together or to wildtype (non-carrier) mice from the colony. The expected coat color from breeding is albino.
When using the MT-TGFα mouse strain in a publication, please cite the originating article(s) and include JAX stock #002422 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(MtTGFA)42Lmb |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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