STOCK Tg(MtTGFA)42Lmb/J

Stock number: 002422
Product name: MT-TGFα
Research areas: Cancer Research

Description

These MT-TGFα (MT42) mice express a transgene containing the human TGFA (transforming growth factor alpha) cDNA.

Detailed description

In the STOCK Tg(MtTGFA)42Lmb/J line liver lesions develop in a progressive fashion, with neoplasia confirmed at autopsy (average age 13 months). Pancreas showed progressive hyperplasia of the stroma, tubular structures and ductular metaplasia, with penetrance of 100%. Unlike mice from the FVB/N-Tg(MtTGFA)100Lmb/J line, STOCK Tg(MtTGFA)42Lmb/J mice do not develop mammary tumors.

Allele

Symbol: Tg(MtTGFA)42Lmb
Name: transgene insertion 42, Glenn Merlino
MGI accession ID: MGI:2388567
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Synonyms: line MT42; MT/TGF-alpha line MT42; MT42; MT-TGF-alpha; Tg(Mt1-TGFA)42Lmb; TGF-alpha
Marker symbol: Tg(MtTGFA)42Lmb
Marker name: transgene insertion 42, Glenn Merlino
Marker synonyms: line MT42; MT/TGF-alpha line MT42; MT42; MT-TGF-alpha; Tg(Mt1-TGFA)42Lmb; TGF-alpha
Chromosome: UN
Strain of origin: CD-1
Expressed genes: TGFA,transforming growth factor alpha,human
Molecular note: This transgene contains the inducible mouse Mt1 (metallothionein) promoter, cDNA of the wild-type allele of the human TGFA (transforming growth factor alpha) gene, and a human growth hormone polyadenylation signal. Line 100, carrying 10 copies of the transgene was also produced (see Tg(MtTGFA)100Lmb).