FVB/N-Tg(MtTGFA)100Lmb/J

Stock number: 002421
Product name: MT-TGF-α
Research areas: Cancer Research

Description

These MT-TGFα (MT100) mice express a transgene containing the human TGFA (transforming growth factor alpha) cDNA.

Detailed description

In the CD1-TgN(MtTGFA)42Lmb line liver lesions develop in a progressive fashion, with neoplasia confirmed at autopsy (average age 13 months). Mammary ductal network was more densely developed in CD1-TgN(MtTGFA)42Lmb transgenic mice, with dividing cells in the subtending ducts as well as in the end bud region. Pancreas showed progressive hyperplasia of the stroma, tubular structures and ductular metaplasia. Penetrance was 100%. The mice were not diabetic. There was no obvious inflammatory reaction. Mice from the FVB/N-TgN(MtTGFA)100Lmb line exhibit a 60% mammary tumor incidence.

Allele

Symbol: Tg(MtTGFA)100Lmb
Name: transgene insertion 100, Glenn Merlino
MGI accession ID: MGI:3040889
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(MtTGFA)100Lmb
Marker name: transgene insertion 100, Glenn Merlino
Chromosome: UN
Strain of origin: FVB/N
Expressed genes: TGFA,transforming growth factor alpha,human
Molecular note: This transgene contains the inducible mouse metallothionein 1 promoter, cDNA of the wild-type allele of the human transforming growth factor alpha gene, and a human growth hormone polyadenylation signal. Line 100 carries ten copies of the transgene.