The transgene integrated into the Y chromosome. These transgenics serve as models for male mammary cancer and ras-mediated solid tumors. The transgene also can be used as a Y-chromosome marker. On the B6,SJL background males develop multiple mammary tumors and salivary gland tumors by one year of age. The salivary tumors are adenocarcinomas arising from serous areas of the submandibular gland. The mammary gland tumors are adenosquamous carcinomas. Microscopic lung metastases were present in 14% of tumor bearing animals. On the FVB background males develop multiple mammary tumors at 6-8 weeks. The tumors are adenosquamous carcinomas with multiple foci of squamous differentiation or adenocarcinomas containing glandular tissue. There is no metastasis observed.

These Wap-ras mice express a transgene containing human Harvey rat sarcoma viral oncogene gene integrated into the SJL Y chromosome.


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