Mice homozygous for the Igl-5tm1Cgn mutation are viable and fertile. Homozygotes show a block in B cell development in bone marrow at the pre-B cell stage; however, blockage is leaky and a low percentage of B cells do get to the peripheral immune system.
Klaus Rajewsky, Max Delbruck Centre for Molecular Medicine
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Igll1 | immunoglobulin lambda-like polypeptide 1 |
Mice homozygous for the Igl-5tm1Cgn mutation are viable and fertile. Homozygotes show a block in B cell development in bone marrow at the pre-B cell stage; however, blockage is leaky and a low percentage of B cells do get to the peripheral immune system.
Allele Name | targeted mutation 1, University of Cologne |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | lambda5-; lambda5T |
Gene Symbol and Name | Igll1, immunoglobulin lambda-like polypeptide 1 |
Gene Synonym(s) | |
Strain of Origin | 129S2/SvPas |
Chromosome | 16 |
Molecular Note | Insertion of a neomycin cassette disrupted the first exon of the gene. |
Mutations Made By | Daisuke Kitamura, University of Cologne |
When maintaining a live colony, homozygous mice may be bred together.
When using the λ5T mouse strain in a publication, please cite the originating article(s) and include JAX stock #002401 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Igll1<tm1Cgn> |
Frozen Mouse Embryo | B6.129S2-Igll1<tm1Cgn>/J | $2595.00 |
Frozen Mouse Embryo | B6.129S2-Igll1<tm1Cgn>/J | $2595.00 |
Frozen Mouse Embryo | B6.129S2-Igll1<tm1Cgn>/J | $3373.50 |
Frozen Mouse Embryo | B6.129S2-Igll1<tm1Cgn>/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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