B6.129S2-Igll1^tm1Cgn/J

Stock number: 002401
Product name: λ5T
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

Mice homozygous for the Igl-5^tm1Cgn mutation are viable and fertile. Homozygotes show a block in B cell development in bone marrow at the pre-B cell stage; however, blockage is leaky and a low percentage of B cells do get to the peripheral immune system.

Allele

Symbol: Igll1^tm1Cgn
Name: targeted mutation 1, University of Cologne
MGI accession ID: MGI:1857189
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Igll1
Marker name: immunoglobulin lambda-like polypeptide 1
Chromosome: 16
Strain of origin: 129S2/SvPas
Molecular note: Insertion of a neomycin cassette disrupted the first exon of the gene.