Mice homozygous for the Cd5tm1Cgn targeted mutation are viable and apparently healthy. Both T and B cells in homozygous mutant mice lack surface CD5. Mice show normal immune responses to both T cell-dependent and -independent antigens.
Klaus Rajewsky, Max Delbruck Centre for Molecular Medicine
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Null/Knockout) | Cd5 | CD5 antigen |
Mice homozygous for the Cd5tm1Cgn targeted mutation are viable and apparently healthy. Both T and B cells in homozygous mutant mice lack surface CD5. Mice show normal immune responses to both T cell-dependent and -independent antigens.
Allele Name | targeted mutation 1, University of Cologne |
---|---|
Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | CD5-; CD50; CD5T |
Gene Symbol and Name | Cd5, CD5 antigen |
Gene Synonym(s) | |
Strain of Origin | 129P2/OlaHsd |
Chromosome | 19 |
Molecular Note | A neomycin gene replaced part of exon 7, which encodes the transmembrane domain. An additional frameshift mutation was introduced into exon 3. Flow cytometry analysis on cells derived from thymus, spleen and the peritoneal cavity of homozygous mice confirmed that no detectable protein was expressed from this allele. |
Mutations Made By | Alexander Tarakhovsky, The Rockefeller University |
While maintaining a live colony, these mice are maintained by mating homozygote siblings.
When using the CD5T mouse strain in a publication, please cite the originating article(s) and include JAX stock #002397 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Cd5<tm1Cgn>, 1 pair minimum |
Frozen Mouse Embryo | 129-Cd5<tm1Cgn>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | 129-Cd5<tm1Cgn>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | 129-Cd5<tm1Cgn>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | 129-Cd5<tm1Cgn>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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