B6.S/Ut-Fv1^b Me1^a Mst1r^Fv2-s/J

Stock number: 002389
Research areas: Virology Research

Development

Imported from Dr. A. Axelrad, University of Toronto, in 1994. Cryopreserved 1998.

Allele

Symbol: Mst1r^Fv2-s
Name: Friend virus susceptibility 2
MGI accession ID: MGI:1857882
Generation method: Spontaneous
Synonyms: Fv2^ss
Marker symbol: Mst1r
Marker name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Marker synonyms: CD136; Cdw136; friend virus susceptibility 2; Fv2; Fv-2; NPCA3; p185-Ron; PTK8; RON; SEA; Stk
Chromosome: 9
Strain of origin: multiple strains
Molecular note: This allele expresses both a normal transcript and a mutant transcript initiating in intron 10 that encodes a truncated form of the receptor that lacks most of the extracellular domain.
General note: This virus susceptibility allele is found in strains NIH Swiss, DDD, BALB/c, DBA, AKR, and others. Mouse strains carrying this allele are susceptible to progression of infection by Friend virus. To date the resistance (wild-type) allele has been found only in strains A, C57BL/6 and other members of the C57 and C58 family and in M. spretus. This locus probably also influences susceptibility to Rauscher leukemia virus, and the locus named Rv2 may be the identical.

Allele

MGI accession ID: MGI:95595
Marker symbol: Fv1
Marker name: Friend virus susceptibility 1
Marker synonyms: Fv-1; Rv1; Rv-1
Chromosome: 4

Allele

MGI accession ID: MGI:97043
Marker symbol: Me1
Marker name: malic enzyme 1, NADP(+)-dependent, cytosolic
Marker synonyms: D9Ertd267e; HUMNDME; Mdh-1; MES; Mod1; Mod-1
Chromosome: 9

Allele

MGI accession ID: MGI:99614
Marker symbol: Mst1r
Marker name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Marker synonyms: CD136; Cdw136; friend virus susceptibility 2; Fv2; Fv-2; NPCA3; p185-Ron; PTK8; RON; SEA; Stk
Chromosome: 9