These Src knock-out mice exhibit a deficiency in bone remodeling, indicating impaired osteoclast function, and developed osteopetrosis. They are suitable for use in applications related to the study of the physiological role of the Rous sarcoma oncogene.
Dr. Philippe Soriano, Mount Sinai School of Medicine
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Src | Rous sarcoma oncogene |
Mice homozygous for the Srctm1Sor targeted mutation display osteopetrosis. Homozygous mutant mice are approximately one-third the size of normal wildtype siblings. Incisors fail to erupt. In general, long bones are shorter in length and show a partial absence of bone marrow. Src has been implicated in development, but its role may be masked by other tyrosine kinases. No overt phenotype is found in brain or platelets, where it is most highly expressed. Mice heterozygous for the Srctm1Sor mutation have no apparent abnormalities.
Allele Name | targeted mutation 1, Philippe Soriano |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | src- |
Gene Symbol and Name | Src, Rous sarcoma oncogene |
Gene Synonym(s) | |
Strain of Origin | 129S7/SvEvBrd-Hprtb-m2 |
Chromosome | 2 |
Molecular Note | A neomycin cassette was inserted into the first coding exon. Northern blot analysis confirmed that no wild-type transcript was present in homozygous mice. No autophosphorylation activity corresponding to the encoded protein is detectable in homozygous mice. |
Mutations Made By | Dr. Philippe Soriano, Mount Sinai School of Medicine |
This strain was generated on an inbred 129/Sv background. The B6,129 strain is maintained by mating heterozygous siblings. Expected coat color from breeding:Black, White Bellied Agouti
When using the src- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002381 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Src<tm1Sor> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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