NOcCB1/LtJ

Stock number: 002348
Product name: NOCB1
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

This strain was derived initially from a cross between NOD/Shi and CBA/JLsLt (characterized by a high incidence of pancreatic necrosis). The mice of this strain do not develop spontaneous Insulin-Dependent Diabetes Mellitus (IDDM) or significant insulitis.

Detailed description

Neither spontaneous IDDM nor significant insulitis has been observed in any of the NOcCB or CBcNO recombinant congenic strains. Histologic analysis revealed leukocyte infiltration of the submandibular salivary glands (sialitis) of aging mice. Mice of these strains also developed pancreatic infiltrates, but these were limited to the perivascular and periductal regions of the pancreas (peri-insulitis) and did not focus on the islets. All strains exhibited strong resistance to induction of both IDDM and insulitis by a cyclophosphamide treatment regimen that causes diabetes within two weeks of the second dose in 90% of female NOD mice.

Development

NOcCB1 was derived from an initial cross between mice of strains NOD/Shi and CBA/JLsLt; the latter is "a substrain of CBA/J selected for high incidence of spontaneous...pancreatic necrosis." F1 animals from this mating were backcrossed to CBA/JLsLt mice, and the resultant N2 animals were sib-mated. This stock was transferred from Ed Leiter's research colony to the T1DR in 2005.