STOCK Plat^tm1Mlg/J

Stock number: 002326
Product name: t-PA^-
Research areas: Hematological Research

Description

These Plat knock-out mice exhibit impairment of pulmonary clot lysis. They are suitable for use in applications related to the study of the fibrinolytic system.

Allele

Symbol: Plat^tm1Mlg
Name: targeted mutation 1, Richard C Mulligan
MGI accession ID: MGI:1857288
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Plat
Marker name: plasminogen activator, tissue
Chromosome: 8
Strain of origin: 129S2/SvPas
Molecular note: The gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encoding most of the kringle-2 domain and part of the proteinase domain, including the catalytically essential histidine residue at position 326. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity.