This transgenic strain carries the normal allele of the human SOD1 gene. These mice are useful for studies of neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS).
IMR Colony, The Jackson Laboratory
Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type |
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Transgenic (Inserted expressed sequence, Humanized sequence) |
This transgenic strain carries the normal allele of the human SOD1 gene. Originally published as N1029, it expresses the same SOD1 protein level as the transgenic strain carrying the SOD1*G93A transgene (002726), even though the copy number in the SOD1*G93A transgenic is higher. This strain serves as a control for the B6.Cg-Tg(SOD1*G93A)dl1Gur/J mutant strain (Stock No. 002299).
Expressed Gene | SOD1, superoxide dismutase 1, human |
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Site of Expression |
Allele Name | transgene insertion 2, Mark E Gurney |
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Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | N1029; N29; SOD1WT; tg-SOD1; WT SOD1; WTSOD1 |
Gene Symbol and Name | Tg(SOD1)2Gur, transgene insertion 2, Mark E Gurney |
Gene Synonym(s) | |
Promoter | SOD1, superoxide dismutase 1, human |
Expressed Gene | SOD1, superoxide dismutase 1, human |
Strain of Origin | (C57BL/6 x SJL)F1 |
Chromosome | UN |
General Note | Expression level of the wild-type transgene in transgenic animals is comparable to that in transgenic mice carrying the original highest expressing line Tg(SOD1*G93A)2Gur. |
Molecular Note | The transgene contains the normal allele of the human superoxide dismutase 1 gene (SOD1). Transgene expression in brain was confirmed by enzyme immunoassay using antibodies that recognize human SOD1 protein. |
Mutations Made By | Dr. Mark Gurney, Tetra Discovery Partners |
When held in a live colony, this strain is maintained by mating hemizygous male or female transgenic mice to C57LB/6J mice. Expected coat color from breeding:Black
When using the WT SOD1 mouse strain in a publication, please cite the originating article(s) and include JAX stock #002298 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(SOD1)2Gur |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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