B6.Cg-Tg(SOD1)2Gur/J

Stock number: 002298
Product name: WT SOD1
Research areas: Metabolism Research, Mouse/Human Gene Homologs, Neurobiology Research

Description

This transgenic strain carries the normal allele of the human SOD1 gene. These mice are useful for studies of neuromuscular disorders, including Amyotrophic Lateral Sclerosis (ALS).

Detailed description

This transgenic strain carries the normal allele of the human SOD1 gene. Originally published as N1029, it expresses the same SOD1 protein level as the transgenic strain carrying the SOD1*G93A transgene (002726), even though the copy number in the SOD1*G93A transgenic is higher. This strain serves as a control for the B6.Cg-Tg(SOD1*G93A)^dl1Gur/J mutant strain (Stock No. 002299).

Allele

Symbol: Tg(SOD1)2Gur
Name: transgene insertion 2, Mark E Gurney
MGI accession ID: MGI:2448770
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(SOD1)2Gur
Marker name: transgene insertion 2, Mark E Gurney
Chromosome: UN
Strain of origin: (C57BL/6 x SJL)F1
Expressed genes: SOD1,superoxide dismutase 1,human
Molecular note: The transgene contains the normal allele of the human superoxide dismutase 1 gene (SOD1). Transgene expression in brain was confirmed by enzyme immunoassay using antibodies that recognize human SOD1 protein.
General note: Expression level of the wild-type transgene in transgenic animals is comparable to that in transgenic mice carrying the original highest expressing line Tg(SOD1*G93A)2Gur.