Mice homozygous for the Il7rtm1Imx targeted mutation are viable and fertile. Newborn and young adult homozygous mutant mice have dramatically reduced thymic and splenic lymphoid cellularity in both B and T cell compartments. T cell development is affected prior to surface expression of CD4 and CD8 and prior to the initiation of T cell receptor beta chain rearrangement. B cell development is through pre-pro-B cells (Cd43+ HSAdull). The phenotype in the mouse resembles human interleukin-2 receptor gamma deficiency (XSCID). IL2Rgamma has been shown to be a necessary component of the IL7R providing the biochemical basis for this condition.

These Il7r knock-out mice exhibit reduced thymic and splenic lymphoid cellularity in both B and T cell compartments.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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