B6.129S2-Ighm^tm1Cgn/J

Stock number: 002288
Product name: muMt^-
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

Homozygous mutant mice lack mature B cells. There is no expression of membrane-bound IgM, although some B cells may be produced using a C gene other than mu. It may be useful as a model for B cell immunodeficiency found in humans.

Detailed description

Mice homozygous for the Ighm^tm1Cgn targeted mutation are viable and fertile. Homozygous mutant mice lack mature B cells. There is no expression of membrane-bound IgM, although some B cells may be produced using a C gene other than mu. It may be useful as a model for B cell immunodeficiency found in humans. Also known as muMT.

Development

A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM). This strain was developed by Dr. Klaus Rajewsky and Dr. Werner Muller at the University of Cologne, Germany. The 129-derived D3 ES cell line was used. This congenic strain was further developed by backcrossing the mutation at least twelve times to C57BL/6J.

Allele

Symbol: Ighm^tm1Cgn
Name: targeted mutation 1, University of Cologne
MGI accession ID: MGI:1857187
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Ighm
Marker name: immunoglobulin heavy constant mu
Chromosome: 12
Strain of origin: 129S2/SvPas
Molecular note: A neomycin resistance cassette disrupted one of the membrane exons of the gene encoding immunoglobulin heavy chain of the class mu (IgM).