Mouse Strain Datasheet - 002287
Mouse Strain Datasheet - 002287
Macrophages from mice homozygous for the Ifngtm1Ts targeted mutation show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.
Dr. Timothy Stewart
| Genetic Background | Generation |
|---|---|
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| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Ifng | interferon gamma |
Mice homozygous for the Ifngtm1Ts targeted mutation are viable and fertile. Homozygotes appear normal in a "clean" environment but display reduced macrophage function in response to pathogens. Specifically, macrophages show impaired production of antimicrobial products and reduced expression of MHC II antigens. There is also uncontrollable proliferation of splenocytes from homozygotes in response to mitogens and alloantigens and a reduced resting natural killer cell activity.
| Allele Name | targeted mutation 1, Timothy Stewart |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | Ifngtm1Ts; targeted mutation 1, Timothy Stewart |
| Gene Symbol and Name | Ifng, interferon gamma |
| Gene Synonym(s) | IFI; Ifg; IFG; IFN-gamma; IFNG2; Ifg |
| Strain of Origin | 129S7/SvEvBrd-Hprt+ |
| Chromosome | 10 |
| Molecular Note | Insertion of a neomycin gene into exon 2, which introduced a termination codon after the first 30 amino acids of the mature protein. |
| Mutations Made By | Dr. Timothy Stewart |
When using the Ifng KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #002287 in your Materials and Methods section.
| Service | Genotype | Price |
|---|---|---|
| Heterozygous for Ifng<tm1Ts> |
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