These mice carry a spontaneous, dominant mutation at the Kit locus characterized by white spotting on the feet, tail, and belly in heterozygotes and embryonic lethality in homozygotes.Read More +
This deletion is a dominant mutation causing white spotting on the feet, tail, belly, and occasionally elsewhere. Homozygosity is embryonic lethal. On the C57BL/6 background approximately 60% of heterozygous females have a closed vagina. The ovaries from these heterozygotes are normal and fine for transplantation. On the C57BL/6 background in the presence of the YAKR/J Chromosome (available from Stock No. 007250), KitW-19H heterozygosity results in sex reversed XY females.
|Allele Name||dominant spotting 19 Harwell|
|Allele Type||Radiation induced|
|Gene Symbol and Name||Kit, KIT proto-oncogene receptor tyrosine kinase|
|Strain of Origin||(C3H/HeH x 101/H)F1|
|Molecular Note||This allele comprises a deletion extending, minimally, from D5Mit58 to D5Mit112/D5Mit306, a genetic distance of approximately 2.8 cM.|