B6.Cg-Kit^W-19H/EiJ

Stock number: 002283
Product name: dominant spotting 19 Harwell
Research areas: Dermatology Research, Developmental Biology Research, Reproductive Biology Research, Research Tools

Description

These mice carry a spontaneous, dominant mutation at the Kit locus characterized by white spotting on the feet, tail, and belly in heterozygotes and embryonic lethality in homozygotes.

Detailed description

This deletion is a dominant mutation causing white spotting on the feet, tail, belly, and occasionally elsewhere. Homozygosity is embryonic lethal. On the C57BL/6 background approximately 60% of heterozygous females have a closed vagina. The ovaries from these heterozygotes are normal and fine for transplantation. On the C57BL/6 background in the presence of the Y^AKR/J Chromosome (available from Stock No. 007250), Kit^W-19H heterozygosity results in sex reversed XY females.

Allele

Symbol: Kit^W-19H
Name: dominant spotting 19 Harwell
MGI accession ID: MGI:1856233
Generation method: Radiation induced
Marker symbol: Kit
Marker name: KIT proto-oncogene receptor tyrosine kinase
Marker synonyms: belly-spot; CD117; c-KIT; Dominant white spotting; Gsfsco1; Gsfsco5; Gsfsow3; MASTC; PBT; SCFR; SCO1; SCO5; SOW3; Steel Factor Receptor; Tr-kit
Chromosome: 5
Strain of origin: (C3H/HeH x 101/H)F1
Molecular note: This allele comprises a deletion extending, minimally, from D5Mit58 to D5Mit112/D5Mit306, a genetic distance of approximately 2.8 cM.