129-Yes1^tm1Sor/J

Stock number: 002280
Product name: yes KO
Research areas: Cancer Research

Description

These Yes knock-out mice exhibit a blocking of the Yes kinase protein production in the brain and several adult tissues.

Detailed description

Mice homozygous for the Yes^tm1Sor mutation display no overt phenotype. While this mutation appears to completely block Yes protein production in the brain and several adult tissues (P. Stein, unpublished observations), a catalytically inactive form of the protein (which lacks kinase domain sequences encoded by the mutated exon) is found in fibroblasts. It is unclear is this partial peptide provides any normal Yes function in vivo.

Development

This mutation is on the 129/Sv inbred strain.

Allele

Symbol: Yes1^tm1Sor
Name: targeted mutation 1, Philippe Soriano
MGI accession ID: MGI:1857269
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Yes1
Marker name: YES proto-oncogene 1, Src family tyrosine kinase
Chromosome: 5
Strain of origin: 129S7/SvEvBrd-Hprt1⁺
Molecular note: The yes gene was disrupted by insertion of a neomycin cassette into exon 7, which encodes the beginning of the kinase domain. A partial protein product has been reported in some cell types (see J:54973).