Mice homozygous for the Srctm1Sor targeted mutation display osteopetrosis. Homozygous mutant mice are approximately one-third the size of normal wildtype siblings. Incisors fail to erupt. In general, long bones are shorter in length and show a partial absence of bone marrow. Src has been implicated in development, but its role may be masked by other tyrosine kinases. No overt phenotype is found in brain or platelets, where it is most highly expressed. Mice heterozygous for the Srctm1Sor mutation have no apparent abnormalities.
|Allele Name||targeted mutation 1, Philippe Soriano|
|Allele Type||Targeted (Null/Knockout)|
|Gene Symbol and Name||Src, Rous sarcoma oncogene|
|Strain of Origin||129S7/SvEvBrd-Hprtb-m2|
|Molecular Note||A neomycin cassette was inserted into the first coding exon. Northern blot analysis confirmed that no wild-type transcript was present in homozygous mice. No autophosphorylation activity corresponding to the encoded protein is detectable in homozygous mice.|
|Mutations Made By|| |
Dr. Philippe Soriano, Mount Sinai School of Medicine
This strain was generated on an inbred 129/Sv background. It has been backcrossed onto C57BL/6J. Expected coat color from breeding:Black, White Bellied Agouti
When using the src- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002277 in your Materials and Methods section.