These Tlx1 knock-out mice exhibit dominant hemimelia, asplenia and other defects.
Dr. Stanley J. Korsmeyer, Dana-Farber Cancer Institute
|Allele Name||targeted mutation 1, Stanley J Korsmeyer|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||Hox11-; Tlx-; Tlx1-|
|Gene Symbol and Name||Tlx1, T cell leukemia, homeobox 1|
|Strain of Origin||129S2/SvPas|
|Molecular Note||Exon 1 was disrupted by the insertion of a neomycin selection cassette into codon 53. Transcript was undetected by in situ hybridization of homozygous mutant mice.|
|Mutations Made By|| |
Dr. Stanley Korsmeyer, Dana-Farber Cancer Institute
When maintaining a live colony, homozygous mice may be bred together.
When using the Hox11- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002273 in your Materials and Methods section.