Mice homozygous for the Cd4tm1Knw knock-out have a significant block in CD4+ T cell development and show a Class II restricted deficit in helper T cell activity and other T cell responses.
IMR Colony, The Jackson Laboratory
Mice homozygous for the Cd4tm1Knw targeted mutation have a significant block in CD4+ T cell development; 90% of their circulating T cells are CD8+. Homozygous mutant mice also show a Class II restricted deficit in helper T cell activity and other T cell responses.
|Allele Name||targeted mutation 1, Barbara B Knowles|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||CD4-; CD4D|
|Gene Symbol and Name||Cd4, CD4 antigen|
|Strain of Origin||129S/SvEv-Gpi1c|
|Molecular Note||A neomycin resistance gene was inserted into exon 5.|
|Mutations Made By|| |
Dr. Barbara Knowles, Institute of Medical Biology
The expected coat color from breeding is black
When using the CD4- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002269 in your Materials and Methods section.