The inbred strain DDY was developed from the outbred "dd"; a stock originally bred in Germany and transferred to Japan before 1920. DDY/JclSidSeyFrkJ shares a 75% genetic homology with the epilepsy model EL/SuzSeyFrkJ (Stock No. 001956). DDY may be used a genetic control for EL/SuzSeyFrkJ.Read More +
The inbred strain DDY was developed from the outbred "dd"; a stock originally bred in Germany and transferred to Japan before 1920. The strain name ddY stands for Deutschland, Denken, and Yoken. In Japan, ddY is used as a general purpose mouse; it is not known if traits attributed to ddY in the literature are found in the inbred DDY/JclSidSeyFrkJ. DDY/JclSidSeyFrkJ shares a 75% genetic homology (personal communication, Dr. Wayne Frankel) with the epilepsy model EL/SuzSeyFrkJ (Stock No. 001956). DDY does not develop spontaneous seizures and may be used a genetic control for EL/SuzSeyFrkJ.
The inbred strain DDY was developed from the outbred "dd" originally bred in Germany and transferred to Japan before 1920. The strain name ddY stands for Deutschland, Denken, and Yoken. The stock was maintained first at the National Institute of Health (Yoken) and then, at the Institute of Infectious Diseases of Tokyo University (Denken). Mice of the DDY/Jcl strain were purchased from CLEA Japan by Dr. Robert Green in the 1980s, when he was a member of the laboratory of Dr. Richard Sidman (Sid). Green gave breeder pairs to Dr. Thomas Seyfried (Sey), at Boston College, who maintained them by random colony breeding (avoiding sib matings) for an indeterminate number of years. Dr. Wayne Frankel (Frk), a researcher at The Jackson Laboratory, received mice from Dr. Seyfried and maintained them by sib mating; the strain has been inbred by Dr. Frankel for more than 30 generations.
|Allele Synonym(s)||deletion; Disc1del|
|Gene Symbol and Name||Disc1, disrupted in schizophrenia 1|
|Gene Synonym(s)||SCZD9; C1orf136|
|Strain of Origin||various|
|General Note||This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189).|
|Molecular Note||A 25 bp deletion in exon 6 causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon in exon 7.|
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