Transgenic mice overexpressing the IL4 transgene under the control of the Lck promoter show severe osteoporosis of both cortical and trabecular bone by 2 months in both males and females. There is decreased bone formation by osteoblasts and kyphosis; characterized by long snout ("weasel face") by 6 weeks of age.
Dr. Roger M. Perlmutter, Amgen
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
Transgenic mice overexpressing the IL4 transgene under the control of the Lck promoter show severe osteoporosis of both cortical and trabecular bone by 2 months in both males and females. There is decreased bone formation by osteoblasts and kyphosis; characterized by long snout ("weasel face") by 6 weeks of age.
Expressed Gene | Il4, interleukin 4, mouse, laboratory |
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Site of Expression |
Allele Name | transgene insertion 1315, David Lewis |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | |
Gene Symbol and Name | Tg(LckIl4)1315Dbl, transgene insertion 1315, David Lewis |
Gene Synonym(s) | |
Promoter | Lck, lymphocyte protein tyrosine kinase, mouse, laboratory |
Expressed Gene | Il4, interleukin 4, mouse, laboratory |
Strain of Origin | (C57BL/6J x DBA/2J)F2 |
Chromosome | UN |
Molecular Note | Transgenic mice overexpress the IL4 transgene under the control of the Lck promoter (lymphocyte protein tyrosine kinase). 8 copies of the transgene were estimated to have integrated into the genome. Expression of the transgene was detected in thymus tissue and by thymocytes. |
Mutations Made By | Dr. David Lewis, University of Washington |
When maintaining a live colony, C57BL/6J females (Stock No. 000664) may be bred to hemizygous males. The donating investigator reports that they feed them squash baby food due to bone defects.
When using the Ick-IL4 mouse strain in a publication, please cite the originating article(s) and include JAX stock #002230 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(LckIl4)1315Dbl |
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