C57BL/6J-Tg(LckIl4)1315Dbl/J

Stock number: 002230
Product name: Ick-IL4
Research areas: Internal/Organ Research

Detailed description

Transgenic mice overexpressing the IL4 transgene under the control of the Lck promoter show severe osteoporosis of both cortical and trabecular bone by 2 months in both males and females. There is decreased bone formation by osteoblasts and kyphosis; characterized by long snout ("weasel face") by 6 weeks of age.

Allele

Symbol: Tg(LckIl4)1315Dbl
Name: transgene insertion 1315, David Lewis
MGI accession ID: MGI:3052795
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(LckIl4)1315Dbl
Marker name: transgene insertion 1315, David Lewis
Chromosome: UN
Strain of origin: (C57BL/6J x DBA/2J)F2
Expressed genes: Il4,interleukin 4,mouse, laboratory
Molecular note: Transgenic mice overexpress the IL4 transgene under the control of the Lck promoter (lymphocyte protein tyrosine kinase). 8 copies of the transgene were estimated to have integrated into the genome. Expression of the transgene was detected in thymus tissue and by thymocytes.