This strain is referred to as "50-4" or "Tg(Alb1-HBV)Bri44" in the primary reference. These mice may be useful for studying hepatocellular carcinoma.
Dr. Francis (Frank) V Chisari, The Scripps Research Institute
Genetic Background | Generation |
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|
Allele Type |
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Transgenic (Inserted expressed sequence) |
This strain is referred to as "50-4" or "Tg(Alb1-HBV)Bri44" in the primary reference. These mice may be useful for studying hepatocellular carcinoma.
Expressed Gene | HBV, hepatitis B virus large envelope polypeptide, |
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Site of Expression |
Allele Name | transgene insertion 44, Ralph L Brinster |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | 50.4; 50-4; HBsAg; HBs-tg; Tg(Alb1-HBV)Bri44 |
Gene Symbol and Name | Tg(Alb1HBV)44Bri, transgene insertion 44, Ralph L Brinster |
Gene Synonym(s) | |
Promoter | Alb, albumin, mouse, laboratory |
Expressed Gene | HBV, hepatitis B virus large envelope polypeptide, |
Strain of Origin | Not Specified |
Chromosome | UN |
Molecular Note | Sequence encoding the hepatitis B virus large envelope polypeptide was placed downstream of the mouse albumin promoter, thereby expressing the peptide in hepatocytes. |
Mutations Made By | Dr. Francis (Frank) Chisari, The Scripps Research Institute |
When maintaining a live colony, hemizygous mice may be bred together, to wildtype (non-carrier) mice from the colony or to C57BL/6J inbred mice (Stock No. 000664). Homozygotes are viable, males infertile. The expected coat color from breeding is black.
When using the Alb-PSX transgenic line 50-4 mouse strain in a publication, please cite the originating article(s) and include JAX stock #002226 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Hemizygous or Non carrier for Tg(Alb1HBV)44Bri |
Frozen Mouse Embryo | C57BL/6J-Tg(Alb1HBV)44Bri/J | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Tg(Alb1HBV)44Bri/J | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Tg(Alb1HBV)44Bri/J | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Tg(Alb1HBV)44Bri/J | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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