These mice overexpress metallothionein1 (Mt1), a stress-response protein found to be significantly increased in the liver and kidney during oxidative stress. These mice express 10- to 20-fold higher basal levels of MT protein in pancreas, liver, and stomach, as well as 2- to 6-fold higher MT protein levels in other organs (kidney, intestine, uterus, testes, spleen, heart, and lung) than control mice.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

These transgenic mice express 56 copies of metallothionein 1 (Mt1) from the transgene.

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