B6;129S7-Amh^tm1Bhr/J

Stock number: 002187
Research areas: Cancer Research, Developmental Biology Research, Endocrine Deficiency Research, Reproductive Biology Research

Description

Male mice homozygous for the Amh^tm1Bhr mutation have testes that are fully descended and produce functional sperm. They also develop a uterus which interferes with sperm transfer rendering most infertile. The testes develop Leydig cell hyperplasia.

Detailed description

Male mice homozygous for the Amh^tm1Bhr mutation have testes that are fully descended and produce functional sperm. They also develop a uterus which interferes with sperm transfer - rendering most infertile. The testes develop Leydig cell hyperplasia. Homozygous females are fertile and reproduce normally.

Development

The Amh^tm1Bhr mutant strain was developed in the laboratory of Dr. Richard Behringer at the University of Texas, MD Anderson Cancer Center. The 129-derived AB-1 ES cell line was used. The Amh^tm1Bhr strain was maintained by breeding homozygous females with heterozygous males.

Allele

Symbol: Amh^tm1Bhr
Name: targeted mutation 1, Richard R Behringer
MGI accession ID: MGI:1857126
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: AMH(-); AMHKO; delta1 (null); MIS-KO
Marker symbol: Amh
Marker name: anti-Mullerian hormone
Marker synonyms: MIF; MIS; Mullerian inhibiting substance
Chromosome: 10
Strain of origin: 129S7/SvEvBrd-Hprt1⁺
Molecular note: A 0.6 kb genomic fragment containing part of exon 1 and exon 2 was replaced with a neomycin selection cassette.