Male mice homozygous for the Amhtm1Bhr mutation have testes that are fully descended and produce functional sperm. They also develop a uterus which interferes with sperm transfer rendering most infertile. The testes develop Leydig cell hyperplasia.
Dr. Richard Behringer, Univ of Texas, MD Anderson Cancer Center
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Amh | anti-Mullerian hormone |
Male mice homozygous for the Amhtm1Bhr mutation have testes that are fully descended and produce functional sperm. They also develop a uterus which interferes with sperm transfer - rendering most infertile. The testes develop Leydig cell hyperplasia. Homozygous females are fertile and reproduce normally.
The Amhtm1Bhr mutant strain was developed in the laboratory of Dr. Richard Behringer at the University of Texas, MD Anderson Cancer Center. The 129-derived AB-1 ES cell line was used. The Amhtm1Bhr strain was maintained by breeding homozygous females with heterozygous males.
Allele Name | targeted mutation 1, Richard R Behringer |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | AMH(-); AMHKO; delta1 (null); MIS-KO |
Gene Symbol and Name | Amh, anti-Mullerian hormone |
Gene Synonym(s) | |
Strain of Origin | 129S7/SvEvBrd-Hprt+ |
Chromosome | 10 |
Molecular Note | A 0.6 kb genomic fragment containing part of exon 1 and exon 2 was replaced with a neomycin selection cassette. |
Mutations Made By | Dr. Richard Behringer, Univ of Texas, MD Anderson Cancer Center |
Amhtm1Bhr homozygous males produce functional sperm but are infertile due to anatomical blockages (homozygous males develop a uterus). Homozygous females are fertile and reproduce normally. When maintaining a live colony, homozygous females may be bred to heterozygous males.
When using the B6;129S7-Amhtm1Bhr/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002187 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Amh<tm1Bhr> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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