These mice carry a radiation-induced mutation, brown 11R30m, that is described as a recessive lethal at the tyrosinase-related protein 1 (Tyrp1) locus.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Radiation induced | Tyrp1 | tyrosinase-related protein 1 |
These mice carry a radiation-induced mutation, brown 11R30m, that is described as a recessive lethal at the tyrosinase-related protein 1 (Tyrp1) locus.
The Tyrp1b-11R30M mutation was identified in the progeny of a (101/Rl x C3H/Rl)F1 male exposed to a 0.3 Gy dose from a neutron source then bred immediately to a female from T stock, a non-inbred strain that was homozygous for seven recessive alleles, a, Tyrpb, Tyrc-ch, Oca2p, Myo5ad, Bmp5se, and Ednrbs. It is likely that there were several subsequent crosses to (101/Rl x C3H/Rl)F1 during which the new mutation was characterized as causing prenatal lethality in the homozygous state. The Tyrp1b-11R30M deletion, which includes Whrn, was imported from Oak Ridge National Laboratory into the laboratory of Dr. Jane Barker at The Jackson Laboratory. It was maintained in a 2 generation breeding scheme starting with a cross of Tyrp1b/Tyrp1b-11R30M compound heterozgyotes to C3H/HeJ then test crossing the offspring to B6.Cg-Whrnwi Tyrp1b/+ +/J to identify mice carrying Tyrp1b-11R30M, not Tyrp1b. These were then bred to brown mice (Tyrp1b/Tyrp1b) from a population of (C57BL/6J x DBA/2J)F2 mice to again obtain Tyrp1b/Tyrp1b-11R30M compound heterozgyotes. Currently the Tyrp1b allele can be detected by genotyping. Embryos were cryopreserved from Tyrp1b/Tyrp1b-11R30M compound heterozygous males bred to C3H/HeJ females and the cryo-recovered pups that do not carry Tyrp1b are presumed heterozygous for Tyrp1b-11R30M.
Allele Name | brown 11R30M |
---|---|
Allele Type | Radiation induced |
Allele Synonym(s) | b11R30M |
Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 |
Gene Synonym(s) | |
Strain of Origin | (101/Rl x C3H/Rl)F1 |
Chromosome | 4 |
Molecular Note | Large intergenic deletion. |
When using the brown 11R30M mouse strain in a publication, please cite the originating article(s) and include JAX stock #002142 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Tyrp1<b-l1R30M> OR Heterozygous for Tyrp1<b> |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.