Herc2J, Jackson; spontaneous; recessive: Arose spontaneously on a BALB/cJ background. Homozygous mutants are smaller than littermates and have a subtle tremor that is recognizable by 2.5 to 3 weeks of age. The visible tremor is not progressive with age. Males are functionally sterile and have reduced sperm numbers and sperm abnormalities similar to those seen in mice with the pink-eyed dilution deletion alleles, Herc2p-bs, Herc2p-6H, and Herc2p-25H. In vitro fertilization was not attempted. Females have poor fertility but ovaries are functional when transplanted into histocompatible hosts. Ovaries may exhibit fewer and smaller copora lutea based on limited sample. Herc2J was allele tested with Herc2p-6H/Herc2p-cp and with Herc2PJ/Herc2P-bs and found to be allelic with Herc2p-6H and Herc2p-bs but not with Herc2p-cp or Herc2p-J.
|Gene Symbol and Name||Herc2, HECT and RLD domain containing E3 ubiquitin protein ligase 2|
|Strain of Origin||BALB/cJ|
|Molecular Note||This allele was identified by a noncomplementation test with Herc2p-6H and Herc2p-bs. It is not an allele of Herc2p-cp or Herc2p-J.|
Homozygous males and females have reduced fertility.
When using the BALB/cByJ-Herc2J/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002088 in your Materials and Methods section.