Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | Hbb | hemoglobin beta chain complex |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | Gpi1 | glucose phosphate isomerase 1 |
Marker Symbol | Marker Name | |
---|---|---|
H1 | histocompatibility 1 |
Allele Name | a variant |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | Gpi1, glucose phosphate isomerase 1 |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 7 |
Molecular Note | This allele determines a slower migrating variant of the encoded enzyme and occurs in the wild and in strains 101/H, A/HeJ, AKR/J, BALB/cJ, C57BR/cdJ, C58/J, CE/J, DBA/2J, DE/J, DW/J, LP/J, MA/J, NZB, PL/J, P/J, RARF, RF/J, SJL/J, ST/bJ, and 129/J. Sequencing analysis identified four nucleotide differences between this allele and Gpi1b. Two differences are silent, while a third difference at position nucleotide position 282 predicts an aspartate for the a allele and an asparagine for the b allele at amino acid position 94. A fourth difference in the 3' untranslated region was also noted. |
Marker Synonym(s) | |
---|---|
Chromosome(s) | 7 |
When using the B6.Cg-Gpi1a Hbbd H1b/DehJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #002074 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Gpi1<a>, Homozygous for Hbb<d>, Homozygous for H1<b>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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