homeostasis/metabolism phenotype

• decreased circulating triglyceride level
  • plasma triglycerides are reduced by 15% in both female and male mice
  (MGI Ref ID J:21750)

• decreased circulating HDL cholesterol level
  • HDL cholesterol levels are reduced by 10% in female but not male mice
  (MGI Ref ID J:21750)

• decreased circulating cholesterol level
  • total plasma cholesterol levels are reduced by 15% in female but not male mice
  (MGI Ref ID J:21750)

homeostasis/metabolism phenotype

• decreased circulating cholesterol level
  • total cholesterol levels are reduced by 25% in female mice and about 15% in male mice
  (MGI Ref ID J:21750)
  • cholesterol levels in female mice fed a high-fat diet for 5 months rise significantly less than in wild-type controls
  (MGI Ref ID J:21750)

• decreased circulating HDL cholesterol level
  • HDL cholesterol levels are reduced by 15% in female but not male mice
  (MGI Ref ID J:21750)

• decreased circulating LDL cholesterol level
  • VLDL+LDL cholesterol levels are reduced by half in female but not male mice
  (MGI Ref ID J:21750)
  • VLDL+LDL cholesterol levels in female mice fed a high-fat diet for 5 months rise significantly less than in wild-type controls
  (MGI Ref ID J:21750)

• decreased circulating triglyceride level
  • triglyceride levels remain low after acute fat loading tests compared to wild-type mice that have sharp increases in triglyceride levels
  (MGI Ref ID J:21750)
  • plasma triglycerides are reduced by 15% in both female and male mice
  (MGI Ref ID J:21750)

• decreased circulating VLDL cholesterol level
  • VLDL+LDL cholesterol levels are reduced by half in female but not male mice
  (MGI Ref ID J:21750)
  • VLDL+LDL cholesterol levels in female mice fed a high-fat diet for 5 months rise significantly less than in wild-type controls
  (MGI Ref ID J:21750)

• abnormal lipid homeostasis
  • chylomicron clearance from the plasma is almost twice as fast as occurs in wild-type mice
  (MGI Ref ID J:21750)

homeostasis/metabolism phenotype

• decreased circulating cholesterol level
  • total cholesterol levels are reduced in male mice but not female mice
  (MGI Ref ID J:21750)

• decreased circulating VLDL cholesterol level
  • VLDL+LDL cholesterol levels are reduced by half in male but not female mice
  (MGI Ref ID J:21750)

• decreased circulating LDL cholesterol level
  • VLDL+LDL cholesterol levels are reduced by half in male but not female mice
  (MGI Ref ID J:21750)

• decreased circulating triglyceride level
  • plasma triglycerides are reduced by 30% in both female and male mice
  (MGI Ref ID J:21750)

homeostasis/metabolism phenotype

• decreased circulating triglyceride level
  • plasma triglycerides are reduced by 30% in both female and male mice
  (MGI Ref ID J:21750)

• decreased circulating VLDL cholesterol level
  • VLDL+LDL cholesterol levels are reduced by half in male but not female mice
  (MGI Ref ID J:21750)

• decreased circulating LDL cholesterol level
  • VLDL+LDL cholesterol levels are reduced by half in male but not female mice
  (MGI Ref ID J:21750)

• decreased circulating cholesterol level
  • total plasma cholesterol levels are slightly reduced in male but not female mice
  (MGI Ref ID J:21750)

adipose tissue phenotype

• increased white adipose tissue amount
  • increased amounts of adipose tissue cause the higher weight gain of mice fed a high fat diet for 20 weeks compared to controls fed the same diet
  (MGI Ref ID J:105136)

behavior/neurological phenotype

• increased food intake
  • mice eat 5- to 15% more than controls during the second half of a 20 week feeding of a high fat diet
  (MGI Ref ID J:105136)

growth/size/body region phenotype

• increased susceptibility to diet-induced obesity
  • female mice have a less extreme but still significant weight gain compared to controls after 20 weeks on a high fat diet
  (MGI Ref ID J:105136)
  • male mice are 22% heavier than controls after 20 weeks on a high fat diet
  (MGI Ref ID J:105136)
  • male mice on a high fat diet have significant body weight increases compared to controls after 2 weeks on the diet
  (MGI Ref ID J:105136)

homeostasis/metabolism phenotype

• decreased circulating triglyceride level
  • triglyceride levels are reduced by almost by half in mice fed a chow diet
  (MGI Ref ID J:105136)
  • triglyceride levels fail to increase as they do in control mice when a high fat diet is administered
  (MGI Ref ID J:105136)
  • mice fed a high fat diet for 20 weeks have a triglyceride level that is about one-third of that in control mice
  (MGI Ref ID J:105136)

• increased circulating glucose level
  • mice fed a high-fat diet for 20 weeks have a mean glucose level of 7.25 mmol/l compared to 5.69 mmol/l in control mice
  (MGI Ref ID J:105136)

• insulin resistance
  • the insulin-mediated whole body glucose uptake of these mice under these conditions is reduced by more than half compared to controls
  (MGI Ref ID J:105136)
  • mice subjected to hyperinsulinemic conditions after being fed a high fat diet for 20 weeks have twice as much insulin in their sera and 4 times less ability to clear insulin
  (MGI Ref ID J:105136)

• lipidosis
  • the triglyceride hydrolase actively of the mouse plasma is 78% greater than in controls
  (MGI Ref ID J:105136)
  • a higher uptake of free fatty acids derived from plasma triglyceride leads to a greater increase in adipose tissue mass when mice are fed a high fat diet
  (MGI Ref ID J:105136)

• decreased energy expenditure
  • the greatest difference in energy expenditure between these mice and control mice is at 4 weeks after the switch to a high fat diet
  (MGI Ref ID J:105136)
  • differences in energy expenditure gradually decrease but are still significantly less after 20 weeks to the switch to a high fat diet
  (MGI Ref ID J:105136)
  • mice have increased gains in body weight per gram of food consumed after being on a high fat diet for 2 weeks
  (MGI Ref ID J:105136)

• increased susceptibility to diet-induced obesity
  • female mice have a less extreme but still significant weight gain compared to controls after 20 weeks on a high fat diet
  (MGI Ref ID J:105136)
  • male mice are 22% heavier than controls after 20 weeks on a high fat diet
  (MGI Ref ID J:105136)
  • male mice on a high fat diet have significant body weight increases compared to controls after 2 weeks on the diet
  (MGI Ref ID J:105136)

• increased circulating leptin level
  • mice fed a high-fat diet for 20 weeks have a mean leptin serum level of 15.99 ng/ml compared to 6.41 ng/ml in control mice
  (MGI Ref ID J:105136)

• abnormal blood homeostasis
  (MGI Ref ID J:105136)

• increased circulating ketone body level
  • mice fed a high-fat diet for 20 weeks have a mean ketone bodies level of 1.75 mmol/l compared to 1.29 mmol/l in control mice
  (MGI Ref ID J:105136)