Mice homozygous for the scrambler spontaneous mutation (Dab1scm) are recognized by an unstable gait and whole-body tremor. The cerebella of 30-day-old scrambler homozygotes are hypoplastic and devoid of folia. Scrambler is similar to the reeler (Relnrl) mutation in phenotype and pathology.Read More +
Mice homozygous for the scrambler spontaneous mutation (Dab1scm) are recognized by an unstable gait and whole-body tremor. The cerebella of 30-day-old scrambler homozygotes are hypoplastic and devoid of folia; however, neither seizures nor abnormal brain wave patterns have been observed. Scrambler is similar to the reeler mutation in phenotype and pathology and, like reeler, probably results from defective neuronal migration. Female homozygotes mate and breed. Homozygous scrambler mutants have an ataxic gait which in the male may be contributory factor in the failure to mate. Normal life span for both sexes.
A novel spontaneous neurological mutation, scrambler (Dab1scm), appeared in the inbred mouse strain DC/Le in 1991. The DC/Le strain originated when a mouse, from an obese stock, carrying the newly discovered Dancer mutation (Tbx10Dc, formerly Dc) was outcrossed to a BALB/c x C3H/He hybrid in 1956, followed by one cross to C3H/HeJ, then inbred.
|Gene Symbol and Name||Dab1, disabled 1|
|Strain of Origin||DC/LeJ|
|Molecular Note||Transcripts produced from this allele show abnormal splicing and are predicted to produce a truncated protein. Sequence analysis revealed that the larger scrambler transcript contains 1.5 kb of intracisternal A particle retrotransposon (IAP) sequence in antisense orientation. Previous mapping studies detcted an IAP particle that failed to recombine with the Dab1 locus. Thus, it appears that abberrant splicing has incorporated the IAP element in the coding region of the gene.|
Comments: homozygotes should not be weaned until 5-6 weeks of age. Homozygous males do not breed.
When using the STOCK A/A-Dab1scm/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002043 in your Materials and Methods section.