| Allele Name | transgene insertion 5, Edward H Leiter |
| Allele Type | Transgenic (Inserted expressed sequence) |
| Allele Synonym(s) | Tg(Ead)Lt |
| Gene Symbol and Name | Tg(H2-Ead)5Lt, transgene insertion 5, Edward H Leiter |
| Gene Synonym(s) | |
| Promoter | H2-I, H2 I region, includes H2-Aa, Ab, Bl, Ea, Eb, Eb2, Ob, Pb, mouse, laboratory |
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| Expressed Gene | H2-I, H2 I region, includes H2-Aa, Ab, Bl, Ea, Eb, Eb2, Ob, Pb, mouse, laboratory |
|---|
| Strain of Origin | NOD/ShiLt |
| Chromosome | UN |
| General Note | Overexpression of H2-Ea in line 5 confers nearly complete resistance to IDDM. Although the presence of the transgene in both lines 5 and 12 confers protective influence from IDDM pathologies that affect pancreatic beta cells, autoimmune pathologies effecting other tissues (submandibular salivary, thyroid, kidney) are observed. Histologic examination of the pancreas reveals perivascular/periductal infiltration and peri-insulitus. |
| Molecular Note | The construct contains a complete H2-Ead gene from the BALB/cByJ mouse including flanking sequence. One copy of the transgene integrated into the genome of line 12 whereas four copies are present in line 5. |
