This congenic strain carries the diabetes-resistant MHC from the from SWR/J (Stock No. 000689) and is used as a comparison to the NOD/ShiLtJ (Stock No. 001976). These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.
Read More +Genetic Background | Generation |
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001289 NOD/ShiLt |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | H2 | histocompatibility-2, MHC |
This congenic strain carries the diabetes-resistant MHC from the from SWR/J (Stock No. 000689) and is used as a comparison to the NOD/ShiLtJ (Stock No. 001976). These mice exhibit some but not all of the immune dysfunctions of NOD/ShiLtJ mice. These mice are useful for dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.
Allele Name | q variant |
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Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | Not Applicable |
Chromosome | 17 |
General Note | The q variant has been observed in the following strains: DBA/1, DBA/1J, BUB/BnJ, STOLI/Lw, SWR/J Genbank ID for this allele: M14827 |
When using the NOD.SW-H2q/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002032 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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