SJL.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim/J

Stock number: 002031

Allele

Symbol: Tg(H2-Ab1)62Dim
Name: transgene insertion 62, Diane Mathis
MGI accession ID: MGI:3793693
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(H2-Ab1)62Dim
Marker name: transgene insertion 62, Diane Mathis
Chromosome: UN
Strain of origin: (C57BL/6 x SJL)F2
Expressed genes: H2-Ab1,histocompatibility 2, class II antigen A, beta 1,mouse, laboratory
Molecular note: A transgenic construct containing the entire mouse (AKR/J strain) H2-Ab1 kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos, generating line A_alpha62. Line 62 was crossed to mice carrying Tg(H2-Aa)26Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 42 was established (A_alpha42). S1-mapping shows normal patterns of high expression in spleen, lung and thymus.

Allele

Symbol: Tg(H2-Aa)26Dim
Name: transgene insertion 26, Diane Mathis
MGI accession ID: MGI:3793688
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(H2-Aa)26Dim
Marker name: transgene insertion 26, Diane Mathis
Chromosome: UN
Strain of origin: (C57BL/6 x SJL)F2
Expressed genes: H2-Aa,histocompatibility 2, class II antigen A, alpha,mouse, laboratory
Molecular note: A transgenic construct containing the entire mouse (AKR/J strain) H2-Aa kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos. Two lines A_alpha10 and A_alpha26 were generated. Line 26 was crossed to mice carrying Tg(H2-Ab1)62Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 46 was established (A_alpha46). S1-mapping shows normal patterns of high expression in spleen, lung and thymus.