Genetic Background | Generation |
---|---|
|
Allele Type |
---|
Transgenic (Inserted expressed sequence) |
Allele Type |
---|
Transgenic (Inserted expressed sequence) |
Expressed Gene | H2-Aa, histocompatibility 2, class II antigen A, alpha, mouse, laboratory |
---|---|
Site of Expression | |
Expressed Gene | H2-Ab1, histocompatibility 2, class II antigen A, beta 1, mouse, laboratory |
Site of Expression |
Allele Name | transgene insertion 26, Diane Mathis |
---|---|
Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | Aa26 |
Gene Symbol and Name | Tg(H2-Aa)26Dim, transgene insertion 26, Diane Mathis |
Gene Synonym(s) | |
Promoter | H2-Aa, histocompatibility 2, class II antigen A, alpha, mouse, laboratory |
Expressed Gene | H2-Aa, histocompatibility 2, class II antigen A, alpha, mouse, laboratory |
Strain of Origin | (C57BL/6 x SJL)F2 |
Chromosome | UN |
Molecular Note | A transgenic construct containing the entire mouse (AKR/J strain) H2-Aa kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos. Two lines Aalpha10 and Aalpha26 were generated. Line 26 was crossed to mice carrying Tg(H2-Ab1)62Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 46 was established (Aalpha46). S1-mapping shows normal patterns of high expression in spleen, lung and thymus. |
Allele Name | transgene insertion 62, Diane Mathis |
---|---|
Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | Ab62 |
Gene Symbol and Name | Tg(H2-Ab1)62Dim, transgene insertion 62, Diane Mathis |
Gene Synonym(s) | |
Promoter | H2-Ab1, histocompatibility 2, class II antigen A, beta 1, mouse, laboratory |
Expressed Gene | H2-Ab1, histocompatibility 2, class II antigen A, beta 1, mouse, laboratory |
Strain of Origin | (C57BL/6 x SJL)F2 |
Chromosome | UN |
Molecular Note | A transgenic construct containing the entire mouse (AKR/J strain) H2-Ab1 kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos, generating line Aalpha62. Line 62 was crossed to mice carrying Tg(H2-Aa)26Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 42 was established (Aalpha42). S1-mapping shows normal patterns of high expression in spleen, lung and thymus. |
When using the SJL.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #002031 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Carrier or non-carrier for Tg(H2-Aa)26Dim, Carrier or noncarrier for Tg(H2-Ab1)62Dim |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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