This lambda 2 transgene with the H enhancer is expressed in lymphoid cells only. The majority of the B cells of newborn transgenic mice produce lambda, whereas kappa + cells are reduced., Serum levels of kappa and kappa mRNA are diminished. By 2 weeks after birth the proportion of kappa-expressing cells is dramatically increased. Adults have reduced proportions of B cells that produce lambda only, but the levels of lambda are still higher than in normal littermates. Also, kappa + cells are still lower than in normal mice. Analysis of hybridomas reveals that reduction of kappa gene rearrangement is the basis for the decreased frequency of kappa + cells. Furthermore, many cells also contain an un-rearranged H chain allele.

These &lambda;2 mice express a transgene containing a functionally arranged lambda 2 (Igl-2) gene from clone MOPC315 under the control of the heavy chain enhancer (mu J-C intron).

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C57BL/6-Tg(lambda2E[H])2Storb/J Frozen Embryos