This lambda 2 transgene with the H enhancer is expressed in lymphoid cells only. The majority of the B cells of newborn transgenic mice produce lambda, whereas kappa + cells are reduced., Serum levels of kappa and kappa mRNA are diminished. By 2 weeks after birth the proportion of kappa-expressing cells is dramatically increased. Adults have reduced proportions of B cells that produce lambda only, but the levels of lambda are still higher than in normal littermates. Also, kappa + cells are still lower than in normal mice. Analysis of hybridomas reveals that reduction of kappa gene rearrangement is the basis for the decreased frequency of kappa + cells. Furthermore, many cells also contain an un-rearranged H chain allele.

These &lambda;2 mice express a transgene containing a functionally arranged lambda 2 (Igl-2) gene from clone MOPC315 under the control of the heavy chain enhancer (mu J-C intron).

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.