STOCK Tg(GPD1*)124ABir/J

Stock number: 002011
Product name: FSE d124A

Description

These FSE d124A mice express a transgene containing carry the human GPD1 gene under the control of a promoter with a deletion in the fat-specific element (FSE) region.

Detailed description

The transgenic construct in this strain encodes the human GPD1 gene with a deletion in fat-specific element (FSE) region of the GPD1 promoter (a deletion from -258 to -135, or 124 bp). During postnatal development and in adult tissues of the transgenic mice, human GPDH is expressed at levels that correspond closely to the expression of the endogenous mouse gene, Gpd-1.

Allele

Symbol: Tg(GPD1*)124ABir
Name: transgene insertion 124A, Edward H Birkenmeier
MGI accession ID: MGI:3799699
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(GPD1*)124ABir
Marker name: transgene insertion 124A, Edward H Birkenmeier
Chromosome: UN
Strain of origin: (C57BL/6J x SJL/J)F2
Expressed genes: GPD1,glycerol-3-phosphate dehydrogenase 1,human
Molecular note: The transgenic construct encodes a deletion in fat-specific element(FSE)region of human GPD1 promoter (deletes from -258 to -135, or 124 bp). A second strain, d124B, was also created (2-5 copies in each) and two shorter deletion (36 bp) mutants (d36A, d36B) were generated.