These FSE d124A mice express a transgene containing carry the human GPD1 gene under the control of a promoter with a deletion in the fat-specific element (FSE) region.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type |
---|
Transgenic (Inserted expressed sequence, Humanized sequence) |
The transgenic construct in this strain encodes the human GPD1 gene with a deletion in fat-specific element (FSE) region of the GPD1 promoter (a deletion from -258 to -135, or 124 bp). During postnatal development and in adult tissues of the transgenic mice, human GPDH is expressed at levels that correspond closely to the expression of the endogenous mouse gene, Gpd-1.
Expressed Gene | GPD1, glycerol-3-phosphate dehydrogenase 1, human |
---|---|
Site of Expression |
Allele Name | transgene insertion 124A, Edward H Birkenmeier |
---|---|
Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | FSE d124A; Tg(FSE124A)17Bir |
Gene Symbol and Name | Tg(GPD1*)124ABir, transgene insertion 124A, Edward H Birkenmeier |
Gene Synonym(s) | |
Promoter | GPD1, glycerol-3-phosphate dehydrogenase 1, human |
Expressed Gene | GPD1, glycerol-3-phosphate dehydrogenase 1, human |
Strain of Origin | (C57BL/6J x SJL/J)F2 |
Chromosome | UN |
Molecular Note | The transgenic construct encodes a deletion in fat-specific element(FSE)region of human GPD1 promoter (deletes from -258 to -135, or 124 bp). A second strain, d124B, was also created (2-5 copies in each) and two shorter deletion (36 bp) mutants (d36A, d36B) were generated. |
When using the FSE d124A mouse strain in a publication, please cite the originating article(s) and include JAX stock #002011 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Hemizygous for Tg(GPD1*)124ABir |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.