These mice carry the C57BL/10-derived H2b region and may be useful in dissecting the role of MHC versus non-MHC genes in producing aberrant immunophenotypes.
These BALB/c mice are congenic for the C57BL/10-derived H2b region. This region of the major histocompatibility complex has been linked to bacterial and viral infection resistance and susceptibility. In this BALB.B10 strain the susceptible BALB/c-derived H2d region is replaced by the resistant C57BL/10-derived H2b region. Like C57BL/10 mice, they are resistant to Friend isolate of murine leukemia retrovirus (FV). In contrast, like BALB/c mice, they are susceptible Mycobacterium tuberculosis infection, with survival times doubling after Interleukin 12(IL-12) administration.
BALB/c was crossed with C57BL/10 and after 13 consecutive backcrosses with selection for C57BL/10-derived H2b at each generation, this congenic was inbred by continuous sibling intercross (Freedman and Lilly, 1975).
|Allele Name||b variant|
|Allele Type||Not Applicable|
|Gene Symbol and Name||H2, histocompatibility-2, MHC|
|Strain of Origin||Not Applicable|
|General Note||The b variant has been observed in the following strains: C57BL/10, C57BL/10SnJ, BXSB/MpJ, C57BL/6J, C57L/J, LP/J, 129P3/J, 129P1/ReJ.|
When maintaining a live colony, homozygous mice may be bred together.
When using the C.B10-H2b/LilMcdJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #001952 in your Materials and Methods section.