This transgenic strain overexpresses the simian plasma cholesteryl ester transfer protein (<i>CETP</i>). Homozygous transgenic are viable and fertile. Mice exhibit a negative correlation between plasma CETP activity and total plasma cholesterol, plasma apolipoprotein (apo) A-I levels, and plasma apo A-I to apo B ratio. The size of the apo A-I-containing lipoproteins is significantly reduced in mice with high plasma CETP activity. Transgenic mice on a high-fat, high-cholesterol diet have substantially higher plasma cholesterol and plasma apo B levels and the apo B-containing lipoproteins are generally larger than those in nontransgenic C57BL/6 mice on the same diet.

This transgenic strain overexpresses the simian plasma cholesteryl ester transfer protein (<i>CETP</i>). Mice exhibit a negative correlation between plasma CETP activity and total plasma cholesterol, plasma apolipoprotein (apo) A-I levels, and plasma apo A-I to apo B ratio.

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