These mice carry an extra chromosomal segment, seen in wild mouse populations, in chromosome 1, and referred to as a homogeneously staining region (HSR).
Read More +Genetic Background | Generation |
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Marker Symbol | Marker Name | |
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Is(HSR;1)1Lub | insertion, homogeneous staining region, Chr 1, Lubeck 1 |
Is(HSR;1)1Lub does not appear to impact viability or impart any other outward phenotype.
Is(HSR;1)1Lub was backcrossed from the, now extinct, RBA1/Dn mutant subline of RBA/DnJ (see Mouse News Letter 1986, v75 p34) onto C57BL/6J for 10 generations before embryos were generated for cryopreservation from homozygous males bred with C57BL/6J females. Cryorecovered pups will be hemizygotes at backcross generation N11.
Marker Synonym(s) | |
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Chromosome(s) | 1 |
When using the B6.Cg-Is(HSR;1)1Lub/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #001914 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Is(HSR;1)1Lub |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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